张伟

博士,副研究员,硕士生导师,生物化学与分子生物学专业。

2000年毕业于北京大学医学部临床医学专业七年制,获得临床医学骨科学专业学士与硕士学位。2004年至2008年就读于香港科技大学生命科学院,获得生物化学博士学位。现为深圳北京大学香港科技大学医学中心副研究员,主要研究方向为疾病相关的基因调控与信号传导。

代表性论文:

1. Wan J., Zhang W., Wu L., Bai T., Zhang M., Lo KW., Chui YL., Cui Y., Tao Q., Yamamoto M., Akira S. and Wu Z. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol Cell Biol. 2006; 26(2): 448-56. 

2. Zhang, W., Chan, H.M., Gao, Y., Poon, R. and Wu, Z. BS69 is involved in cellular senescence through the p53-p21Cip1 pathway. EMBO Reports 2007; 8: 952-8.

3. Sun, L., Ma, K., Wang, H., Xiao, F., Gao, Y., Zhang, W., Wang, K., Gao, X., Ip, N., and Wu, Z. JAK1/STAT1/STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J. Cell Biol. 2007; 179: 129-138.

4. Yu B, Guan M, Peng Y, Shao Y, Zhang C, Yue X, Zhang J, Yang H, Zou H, Ye W, Wan J, Zhang W*. Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus. Arthritis & Rheumatism 2011; 63(11): 3487-92.

5. Yu, B., Shao, Y., Zhang, J., Dong, X. L., Liu, W. L., Yang, H., Liu, L., Li, M. H., Yue, C. F., Fang, Z. Y., Zhang, C., Hu, X. P., Chen, B. C., Wu, Q., Chen, Y. W., Zhang, W.*, Wan, J. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. Br J Dermatol. 2010; 162(5):1038-43.

6. Yu B, Shao Y, Li P, Zhang J, Zhong Q, Yang H, Hu X, Chen B, Peng X, Wu Q, Chen Y, Guan M, Wan J, Zhang W*. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. Br J Dermatol. 2010; 163(5): 935-940.

7. Yu B, Shao Y, Yue X, Zhang J, Guan M, Wan J, Zhang W*. Copy number variations of Interleukin-12B and T-bet are associated with systemic lupus erythematosus. Rheumatology (Oxford) 2011; 50(7): 1201-5.

8. Guan M, Yu B, Wan J, Zhang X, Wu Z, Zhong Q, Zhang W, Zou H. Identification of BANK1 polymorphisms by unlabelled probe high resolution melting: association with systemic lupus erythematosus susceptibility and autoantibody production in Han Chinese. Rheumatology (Oxford) 2011; 50(3): 473-480.

9. Yu, B., Shao, Y., Zhang, C., Chen, Y., Zhong, Q., Zhang, J., Yang, H., Zhang, W.*, Wan, J. BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation. Exp Cell Res. 2009; 315(20): 3543-53.

10. Yu B, Wu Q, Chen Y, Li P, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Zhang W*, Wan J. Polymorphisms of PXK are associated with autoantibody production, but not disease risk, of systemic lupus erythematosus in Chinese mainland population. Lupus. 2011; 20(1): 23-7.

11. Yu B, Chen Y, Wu Q, Li P, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Wan J, Zhang W*. The association between single-nucleotide polymorphisms of NCF2 and systemic lupus erythematosus in Chinese mainland population. Clin Rheumatol. 2011; 30(4): 521-7.

12. Wu Q, Yu B, Chen Y, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Wan J, Zhang W*. Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population. Clin Rheumatol. 2011; 30(10): 1373-8.

13. Li, Z., Zhang, W., Shao, Y., Zhang, C., Wu, Q., Yang, H., Wan, X., Zhang, J., Guan, M., Wan, J. and Yu, B. High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers. Med Oncol. 2010; 27(3):998-1004.

14. Zhang, C., Shao, Y., Zhang, W., Wu, Q., Yang, H., Zhong, Q., Zhang, J., Guan, M., Yu, B. and Wan, J. High-resolution melting analysis of ADAMTS9 methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Genet Cytogenet. 2010; 196(1):38-44.

15. Zhang, W., Li, T., Shao, Y., Zhang, C., Wu, Q., Yang, H., Zhang, J., Guan, M., Yu, B. and Wan, J. Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis. J Cancer Res Clin Oncol. 2010; 136(8):1267-73.

16. Yu, B., Yang, H., Zhang, C., Wu, Q., Shao, Y., Zhang, J., Guan, M., Wan, J., Zhang, W*. High-resolution melting analysis of PCDH10 methylation levels in gastric, colorectal and pancreatic cancers. Neoplasma. 2010; 57(3): 247-52.

17. Shao Y, Zhang W, Zhang C, Wu Q, Yang H, Zhang J, Guan M, Wan J, Yu B. High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Invest. 2010; 28(6):642-8.

18. Yang, H., Zhang, C., Zhao, X., Wu, Q., Fu, X., Yu, B., Shao, Y., Guan, M., Zhang, W., Wan, J. and Huang, X. Analysis of copy number variations of BS69 in multiple types of hematological malignancies. Ann Hematol. 2010; 89(10): 959-64.

19. Zhang J, Gao Y, Zhao X, Guan M, Zhang W, Wan J, Yu B. Investigation of copy-number variations of C8orf4 in hematological malignancies. Med Oncol. 2011; 28(1): 647-52.

20. Zhao X, Wu Q, Fu X, Yu B, Shao Y, Yang H, Guan M, Huang X, Zhang W*, Wan J. Examination of copy number variations of CHST9 in multiple types of hematologic malignancies. Cancer Genet Cytogenet. 2010; 203(2):176-9.

21. Wan J, Gao Y, Zhao X, Wu Q, Fu X, Shao Y, Yang H, Guan M, Yu B, Zhang W*. The association between the copy-number variations of ZMAT4 and hematological malignancy. Hematology. 2011; 16(1):20-23.

22. Guan M, Liu L, Zhao X, Wu Q, Yu B, Shao Y, Yang H, Fu X, Wan J, Zhang W*. Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies. Clin Lymphoma Myeloma Leuk. 2011; 11(1): 50-3.

23. Shao Y, Zhang W, Dong X, Liu W, Zhang Ch, Zhang J, Zhong Q, Wu Q, Yang H, Chen Y, Wan J, Yu B. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection. Acta Virol. 2010; 54(4):261-7.

24. Li T, Cao H, Zhuang J, Wan J, Guan M, Yu B, Li X, Zhang W*. Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans. Clin Chim Acta. 2011; 412(1-2): 66-70.

25. Zhang J, Zhang R, Shao Y, Chen B, Hu X, Wan J, Zhang C, Zhang W, Yu B. Investigation of EGFR copy-number variations in skin cancers. Eur. J. Oncol. 2011; 16(1): 15-19.

26. Wu Z, Yuan H, Zhang X, Liu W, Xu J, Zhang W, Guan M. Development and Inter-Laboratory Validation of Unlabeled Probe Melting Curve Analysis for Detection of JAK2 V617F Mutation in Polycythemia Vera. PLoS ONE 2011; 6(10): e26534.

27. Zhao XT, Zhou DQ, Wu S, Chen YW, Shao Y, Zhang J, Xia CS, Wang KP, Yang H, Wan J, Yu B, Zhang Z, Zhang W*. Genotyping cytomegalovirus UL97 mutations by high-resolution melting analysis with unlabeled probe. Arch Virol. 2012; 157(3):475-81.

28. Chen Y, Wu Q, Shao Y, Zhang J, Guan M, Wan J, Yu B, Zhang W*. Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis. Int J Immunogenet. 2012; 39(4): 321-7.

29. Shao Y, Zhang J, Zhang R, Wan J, Zhang W*, Yu B. Examination of Smad2 and Smad4 copy-number variations in skin cancers. Clin Transl Oncol. 2012; 14(2): 138-42.

30. Shao Y, Zhang J, Chen Y, Wu Q, Guan M, Yu B, Wan J, Zhang W*. The association of IL-12b polymorphisms with systemic lupus erythematosus in Chinese Han population. International Journal of Rheumatology. 2012: 1-6. doi:10.1155/2012/724872.

31. Shao Y, Zhang J, Chen Y, Wu Q, Guan M, Yu B, Wan J, Zhang W*. The association of IL-12b polymorphisms with systemic lupus erythematosus in Chinese Han population. International Journal of Rheumatology. 2012: 1-6. doi:10.1155/2012/724872.

32. Zhang J, Chen YW, Shao Y, Wu Q, Guan M, Zhang W, Wan J, and Yu B. Identification of TNIP1 Polymorphisms by High Resolution Melting Analysis with Unlabelled Probe: Association with Systemic Lupus Erythematosus. Autoimmune Diseases. 2012: 1-5. doi:10.1155/2012/265823.

33. Gao Y, Li Y, Guo X, Wu Z, Zhang W*. Loss of STAT1 in bone marrow-derived cells accelerates skeletal muscle regeneration. PLoS ONE. 2012;7(5):e37656.

34. Zhang J, Wang Y, Zhen P, Luo X, Zhang C, Zhou L, Lu Y, Yang Y, Zhang W, Wan J. Genome-wide analysis of miRNA signature differentially expressed in doxorubicin-resistant and parental human hepatocellular carcinoma cell lines. PLoS One. 2013; 8(1): e54111.

35. Chen B, Ye T, Shao Y, Zhang J, Zhong Q, Hu X, Zhang W, Yu B. Association between copy-number variations of the human histamine H4 receptor gene and atopic dermatitis in a Chinese population. Clin Exp Dermatol. 2013; 38(3): 295-301.

36. Tang L, Zhang W, Su B, Yu B. Long Noncoding RNA HOTAIR Is Associated with Motility, Invasion, and Metastatic Potential of Metastatic Melanoma. Biomed Res Int. 2013;2013:251098.

37. Liu Z, Xiang Y, Wei Z, Yu B, Shao Y, Zhang J, Yang H, Li M, Guan M, Wan J, Zhang W*. Application of shRNA-containing herpes simplex virus type 1 (HSV-1)-based gene therapy for HSV-2-induced genital herpes. J Virol Methods. 2013; 193(2): 353-358.

38. Luo H, Wu Q, Ye X, Xiong Y, Zhu J, Xu J, Diao Y, Zhang D, Wang M, Qiu J, Miao J, Zhang W*, Wan J. Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease. PLoS One. 2014 Aug; 9(8):e101725.

39. Wang H, Zhang W, Wan J, Liu W, Yu B, Jin Q, Guan M. Microchip-Based Human Serum Atherogenic Lipoprotein Profile Analysis. Analytical Biochemistry. DOI: 10.1016/j.ab.2014.08.031.

40. Wang J, Qin S, Li F, Li S, Zhang W, Peng J, Zhang Z, Gong Q, Wu J, Shi Y. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding. Cell Res. 2014 Jul;24(7):890-3.

41. Wang KP, Kim MK, Caro GD, Wong J, Shalapour S, Wan J, Zhang W, Zhong ZY, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov S, Karin M. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014; 41(6): 1052-63.

42. Yu Y, Yip KH, Tam IY, Sam SW, Ng CW, Zhang W*, Lau HY. Differential Effects of the Toll-like Receptor 2 Agonists, PGN and Pam3CSK4 on anti-IgE Induced Human Mast Cell Activation. PLoS One. 2014; 9(11):e112989.

43. Zhou Y, Pan DS, Shan S, Zhu JZ, Zhang K, Yue XP, Nie LP, Wan J, Lu XP, Zhang W*, Ning ZQ. Non-toxic dose chidamide synergistically enhances platinum-induced DNA damage responses and apoptosis in Non-Small-Cell lung cancer cells. Biomed Pharmacother. 2014; 68(4):483-91.

44. Guan M, Chen X, Ma Y, Tang L, Guan L, Ren X, Yu B, Zhang W*, Su B. MDA-9 and GRP78 as potential diagnostic biomarkers for early detection of melanoma metastasis. Tumor Biology. 2015; 36(4): 2973-82.

45. Duan HF, Li XQ, Hu HY, Li YC, Cai Z, Mei XS, Yu P, Nie LP, Zhang W*, Yu ZD, Nie GH. Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma. Tumor Biology. 2015; 36(9): 6679-89.

46. Nie G, Duan H, Li X, Yu Z, Luo L, Lu R, Ji Z, Zhang W*. MiR-205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting TP53INP1. Molecular Medicine Reports. 2015; 12(4): 5715-22.

47. Lu R, Ji Z, Li X, Qin J, Cui G, Chen J, Zhai Q, Zhao C, Zhang W*, Yu Z. Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2. Tumor Biology. 2015; 36(9): 6691-700.

48. Chen XF, Li TR, Yang H, Shao Y, Zhang J, Zhang W, Yu B, Wei Z, Wu B, Yu L. Detection of Two Drug-Resistance Mutants of the Cytomegalovirus by High-Resolution Melting Analysis. J Clin Lab Anal. 2015 May 13. doi: 10.1002/jcla.21858. [Epub ahead of print]

49. Li F, Qu H, Cao HC, Li MH, Chen C, Chen XF, Yu B, Yu L, Zheng LM, Zhang W*. Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in Endothelial Cells. Cell Biology International. 2015; 39(10): 1131-7.

50. Xie CW, Zhou Y, Liu SL, Fang ZY, Su B, Zhang W*. Gabarapl1 mediates androgen-regulated autophagy in prostate cancer. Tumor Biology. 2015; 36(11): 8727-33.

51. Wang YN, Yu L, Zhao XS, Zhang W, Wan J, Yu B. Establishment of plasma microRNA detection method by using taqman probe based quantitative reverse transcription PCR. Cell. Mol. Biol. 2015; 61 (3): 51-56.

52. Nie GH, Luo L, Duan HF, Li XQ, Yin MJ, Li Z, Zhang W*. GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma. Tumor Biology. 2016; 37(4): 4559-67.

53. Ye T, Chen B, Yu B, Zhong Q, Huang G, Hu X, Zhang W*. Susceptibility of Ureaplasma urealyticum to Methylene Blue-Mediated Photodynamic Antimicrobial Chemotherapy: An in vitro Study. Photochem Photobiol. 2015; 91(4): 917-22. doi: 10.1111/php.12438.

54. Yu Y, Zhang Y, Zhang J, Dou X, Yang H, Shao Y, Wang K, Yu B, Zhang W*, Lau HY. Impaired Toll-like receptor 2-mediated Th1 and Th17/22 cytokines secretion in human peripheral blood mononuclear cells from patients with atopic dermatitis. J Transl Med. 2015; 13: 384. doi: 10.1186/s12967-015-0744-1.

55. Zhang YY, Yu YY, Zhang YR, Zhang W*, Yu B. The Modulatory Effect of TLR2 on LL-37-induced Human Mast Cells Activation. Biochem Biophys Res Commun. 2016; 470(2): 368-74.

56. Cao T, Zhang Z, Liu ZG, Dou X, Zhang J, Zhang W, Wu B, Yu ZD, Wei Z, Yu B. High-level expression and purification of the major house dust mite allergen Der p 2 in Escherichia coli. Protein Expr Purif. 2016; 121: 97-102.

57. Chen XF, Zhang Z, Dou X, Li JJ, Zhang W*, Yu YY, Yu B. Histamine H4 Receptor mediates interleukin-8 and TNF-α release in human mast cells via multiple signaling pathways. Cell Mol Biol. 2016; 62(1): 84-9.

58. Zhong WL, Wang L, Wu X, Zhang J, Chen XF, Zhang W*, Dou X, Yu B. Development of Unlabeled Probe-Based High-Resolution Melting Analysis for Detection of Filaggrin Gene Mutation c.3321delA. J Clin Lab Anal. 2016 Feb 3. DOI 10.1002/jcla.21953. [Epub ahead of print]

59. Yu YY, Huang ZH, Mao Z, Zhang YR, Jin ML, Chen WW, Zhang W, Yu B, Zhang WZ, Lau HY. Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells. Eur J Pharmacol. 2016; 780: 115-21.

60. Fan CY, Wu Q, Ye XY, Luo HX, Yan DD, Xiong Y, Zhu HL, Diao YR, Zhang W*, Wan J. Role of miR-211 in neuronal differentiation and viability: implications to pathogenesis of Alzheimer’s disease. Frontiers in Aging Neuroscience. 2016; 8: 166.

61. Toll-like receptor 2-mediated MAPKs and NF-kB activation requires the GNAO1-dependent pathway in human mast cells. Jin ML, Yu B, Zhang WZ, Zhang W, Xiao Z, Mao ZG, Lai YH, Lin DX, Ma Q, Pan E, Zhang YR, Yu YY. Integr Biol (Camb). 2016; 8(9): 968-75.

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