温子龙

博士,教授,博士生导师,生物化学与分子生物学。

1986年毕业于第一军医大学(现改为南方医科大学)医疗系,获学士学位,1997年在美国洛克斐勒(Rockefeller)大学获得生物学博士学位。1997到1999年作为Helen Hay Whitney Postdoctoral Fellow在斯坦福(Stanford)大学医学院Irving L.Weissman教授的实验室从事博士后研究。1999到2007年在新加坡分子细胞研究所任副教授,2007年2月起在香港科技大学任副教授,教授2012年起任深圳北京大学香港科技大学医学中心客座教授,博士生导师,主要研究方向为以斑马鱼为模式动物,进行血管生成和血细胞的发育的机制研究。目前已在包括Science、Cell等杂志上发表数十篇论文

代表性论文:

1. Xu J, Wang TN, Wu Y, Jin W, and Wen ZL. (2016) Microglia colonization of developing zebrafish midbrain is regulated by apoptotic neurons and lysophosphatidylcholine. Developmental Cell (In press) 

2. Jin H, Huang ZB, Chi YL, Wu M, Zhao LF, Zho RY, Xu J, Zhen FH, Lan YH, Li L, Zhang WQ, Wen ZL*, and Zhang YY*. (2016) c-Myb and Cebp1 act cooperatively to regulate neutrophil maturation in zebrafish. Blood (In press) (Co-corresponding author)

3. Wei YL, Xu J, Zhang WQ, Wen ZL*, and Liu F*. (2016) RNA polymerase III component Rcp9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development 143:2103-2110 (Co-corresponding author) 

4. Xu J, Zhu L, He SC, Wu Y, Jin W, Yu T, Qu JAY, and Wen ZL. (2015) Temporal-spatial resolution fate mapping reveals distinct origins for embryonic and adult microglia in zebrafish. Developmental Cell 34:632–641. 

5. Yan B, Han PD, Pan LF, Lu W, Xiong JW, Zhang MJ, Zhang WQ, Li L, and Wen ZL. (2014) Il-1β; and ROS differentially regulate neutrophil directional migration and basal random motility in zebrafish injury-induced inflammation model. The Journal of Immunology 192:5998-6008. 

6. Zhen FH, Lan YH, Yan B, Zhang WQ, and Wen ZL. (2013) Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms. Development 140:3977-3985. (F1000 recommended) 

7. Sun JP, Liu W, Li L, Chen JH, Wu M, Zhang YY, Leung AYH, Zhang WQ*, Wen ZL*, and Liao WJ*. (2013) Suppression of Pu.1 function results in expanded myelopoiesis in zebrafish. Leukemia 27:1913-1917. (Co-corresponding author) 

8. Li XL, Lan YH, Xu J, Zhang WQ, and Wen ZL. (2012) SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Development 139:4321-4329. 

9. Li L, Yan B, Shi YQ, Zhang WQ, and Wen ZL. (2012) Live imaging reveals distinct actions of macrophages and neutrophils during zebrafish tail fin regeneration. The Journal of Biological Chemistry 287:25353-25360. 

10. Xu J, Du L, and Wen ZL. (2012) Myelopoiesis during zebrafish early development. Journal of Genetics and Genomics39:435-442. (Invited review) 

11. Jin H, Li L, Xu J, Zhen FH, Zhu L, Liu PP, Zhang MJ, Zhang WQ, and Wen ZL. (2012). Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood 119:5239-5249. 

12. ZhangYY, Jin H, Li L, Qin X-F, and Wen ZL. (2011) c-Myb regulates hematopoietic stem/progenitor cell migration during zebrafish hematopoiesis. Blood 118:4093-4101. 

13. Du LS, Xu J, Li XL, Ma N, Liu YM, Peng JR, Osato M, Zhang WQ, and Wen ZL. (2011) Rumba and Haus3 are essential factors for maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis. Development 138:619-629.

14. Li L, Jin H, Xu J, Shi YQ, and Wen ZL. (2011) Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis. Blood 117:1359-1369. 

15. Jin H, Sood R, Xu J, Zhen FH, Liu PP, and Wen ZL. (2009) Definitive hematopoietic stem cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development 136:647-654.

16. Huang HH, Ruan H, Aw YM, Hussain A, Guo L, Gao C, Qian F, Leung T, Song H, Kimelman D, Wen ZL*, and Peng JR*. (2008) Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis. Development135:3209-3218. (Co-corresponding author) 

17. Liu YM, Du LS, Osato M, Teo EH, Qian F, Jin H, Zhen FH, Xu J, Guo L, Huang HH, Chen J, Geisler R, Jiang YJ, Peng JR, and Wen ZL. (2007) The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development. Blood 110:99-106. 

18. Jin H, Xu J, and Wen ZL. (2007). Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development. Blood 109:5209-5214.

19. Qian F, Zhen FH, Xu J, Huang M, Li WY, and Wen ZL. (2007) Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis. PLoS Biology 5:1110-1119. 

20. Jin H, Xu J, Qian F, Du LS, Tan CY, Lin ZX, Peng JR, and Wen ZL. (2006) The 5’ zebrafish scl promoter targets transcription to the brain, spinal cord, hematopoietic and endothelial progenitors. Developmental Dynamics 235:60-67. 

21. Qian F, Zhen FH, Ong CT, Jin S-W, Soo HM, Stainier DYR, Lin S, Peng JR and Wen ZL. (2005) Microarray analysis of zebrafish cloche mutant using amplified cDNA and the identification of potential hematopoietic-endothelial target genes.Developmental Dynamics 233:1163-1172.

22. Wen CM, Zhang ZH, Ma WP, Xu M, Wen ZL, and Peng JR. (2004) Genome-wide identification of demal-enriched genes in zebrafish. Developmental Dynamics 232:171-179. 

23. Lo J, Lee S, Xu M, Liu F, Ruan H, Eun A, He Y, Wang W, Wen ZL*, and Peng JR*. (2003) 15,000 unique zebrafish EST clusters and their use in microarray for profiling gene expression patterns during embryogenesis. Genome Research13:455-466. (Co-corresponding author) 

24. Huang M, Qian F, Hu Y, Ang C, Li Z, and Wen ZL. (2002) The chromatin-remodelling factor BRG1 selectively activates a subset of interferon α-inducible genes. Nature Cell Biology 4:774-781. 

25. Liu F and Wen ZL. (2002) Cloning and expression pattern of the lysozyme C gene in zebrafish. Mechanisms of Development 113:69-72. 

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