万峻

博士,研究员,博士生导师,神经生物学。

2000年毕业于北京大学医学部临床医学专业七年制,获得临床医学血液病学专业学士与硕士学位。2001年至2004年就读于香港科技大学生物化学系,获得博士学位。2005年至2007年于香港科技大学生物化学系进行博士后研究工作。2007年获聘为香港科技大学研究助理教授,现为深圳北京大学香港科技大学医学中心研究员,博士生导师。主要研究方向为神经退行性疾病信号传导通路研究。先后主持国家自然科学基金及省部级和深圳市科技计划11项,获得国家发明专利授权3项。

代表性论文:

1. Wan J, Sun L, Mendoza JW, Chui YL, Huang DP, Chen ZJ, Suzuki N, Suzuki S, Yeh WC, Akira S, Matsumoto K, Liu ZG, Wu Z. Elucidation of the JNK pathway mediated by Epstein-Barr virus encoded latent membrane protein 1 (LMP1). Mol Cell Biology. 2004; 24(1): 192-9.

2. Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol Cell Biol. 2006; 26(2): 448-56.

3. Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci. 2008; 28(36): 9002-12.

4. Yu, B., Shao, Y., Zhang, C., Chen, Y., Zhong, Q., Zhang, J., Yang, H., Zhang, W. and Wan J*. BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation. Exp Cell Res. 2009; 315(20): 3543-53.

5. Wan J, Fu AKY, Ip FCF. Ng HK, Hugon J, Page G, Wang JH, Lai KO, Wu Z, Ip NY. Tyk2/STAT3 signaling mediated beta-amyloid-induced neuronal cell death: implications in Alzheimer’s disease. J Neurosci. 2010; 30(20): 6873-81.

6. Yu B, Guan M, Peng Y, Shao Y, Zhang C, Yue X, Zhang J, Yang H, Zou H, Ye W, Wan J*, Zhang W. Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus. Arthritis Rheum. 2011 Nov;63(11):3487-92.

7. Xiong Y, Zhu JX, Fang ZY, Zeng CG, Zhang C, Qi GL, Li MH, Zhang W, Quan DP, Wan J*. Coseeded Schwann cells myelinate neurites from differentiated neural stem cells in neurotrophin-3-loaded PLGA carriers. Int J Nanomedicine. 2012;7:1977-89. Epub 2012 Apr 16

8. Xiao Y, Peng Y, Wan J, Tang G, Chen Y, Tang J, Ye WC, Ip NY, Shi L. The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics. J Biol Chem. 2013 Jul 5;288(27):20034-45. Epub 2013 May 17.

9. Diao Y, Guo X, Jiang L, Wang G, Zhang C, Wan J, Jin Y, Wu Z. miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in Rhabdomyosarcoma. J. Biol. Chem. 2014 Jan 3;289(1):529-39

10. Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu L, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M. Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis. Immunity. 2014 Dec 18; 41 (6): 1052-1063. doi:  10.1016/ j.immuni. 2014.11.009. Epub 2014 Nov 25.

11. Luo H, Wu Q, Ye X, Xiong Y, Zhu J, Xu J, Diao Y, Zhang D, Wang M, Qiu J, Miao J, Zhang W, Wan J*. Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.PLoS One. 2014 Aug 22; 9(8): e101725. doi: 10.1371/ journal.pone. 0101725. eCollection 2014.

12. Ye X, Luo H, Chen Y, Wu Q, Xiong Y, Zhu J, Diao Y, Wu Z, Miao J, Wan J*. MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies. Front Aging Neurosci. 2015 Nov 18;7:210. doi: 10.3389/fnagi.2015.00210. eCollection 2015.

13. Liu H, Li J, Raval MH, Yao N, Deng X, Lu Q, Nie S, Feng W, Wan J, Yengo CM, Liu W, Zhang M. Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin. Elife. 2016 Jan 19;5. pii: e12856. doi: 10.7554/eLife.12856.

14. Fan C, Wu Q, Ye X, Luo H, Yan D, Xiong Y, Zhu H, Diao Y, Zhang W, Wan J*. Role of miR-211 in Neuronal Differentiation and Viability: Implications to Pathogenesis of Alzheimer's Disease. Front Aging Neurosci. 2016 Jul 8;8:166. doi: 10.3389/fnagi.2016.00166. eCollection 2016.

15. Zhao XS, Wang YN, Meng-Lv, Yuan-Kong, Luo HX, Ye XY, Wu Q, Zhao TF, Hu YH, Zhang HY, Ming-Rui-Huo, Jun-Wan*, Huang XJ*. miR-153-3p, a new bio-target, is involved in the pathogenesis of acute graft-versus-host disease via inhibition of indoleamine- 2,3-dioxygenase. Oncotarget. 2016 Jul 26;7(30):48321-48334.

16. Wu Q, Ye X, Xiong Y, Zhu H, Miao J, Zhang W, Wan J*. The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Front Mol Neurosci. 2016 Dec 8;9:140. doi: 10.3389/fnmol.2016.00140.

17. Cai Y, Sun Z, Jia H, Luo H, Ye X, Wu Q, Xiong Y, Zhang W, Wan J*. Rpph1 Upregulates CDC42 Expression and Promotes Hippocampal Neuron Dendritic Spine Formation by Competing with miR-330-5p.Front Mol Neurosci. 2017 Feb 7;10:27. doi: 10.3389/fnmol.2017.00027. eCollection 2017.


联系邮箱: wanj@ust.hk


 

 

本网站由阿里云提供云计算及安全服务