方征宇

 

博士,副研究员,硕士研究生导师。2008年于复旦大学上海医学院获得生物化学与分子生物学博士学位。后在深圳北京大学香港科技大学医学中心从事博士后工作。2011年获北京大学医学部副研究员职称并获得硕士研究生导师资格。

长期从事肿瘤分子生物学的研究。早期主要从事整合素异常与恶性肿瘤发生发展的关系研究。后与北京大学深圳医院临床科室合作,开展了一系列肿瘤相关长链非编码RNA、肿瘤的耐药和增敏机制研究等。在口腔舌癌中首先发现了UCA1MALAT1等长链非编码RNA的表达异常,相关文章得到了较高的引用率。在肿瘤耐药研究方面构建了多株不同组织来源的肿瘤的耐药株,并筛选出了一系列与耐药相关的非编码RNA,并进行了深入的研究。在乳腺癌耐药方面发现了阿司匹林联用可逆转激素治疗耐药的乳腺癌细胞株,并进行了深入的分子机制研究。

以项目负责人身份获得国家、省、市各级科研项目多项,在《J Cell Biochem》、《BMC Cancer》、《Oncotarget》等SCI杂志发表第一或通讯作者文章17篇,目前共被引用400多次。共计指导硕士研究生(包含基础和临床)9名, 其中7名已毕业。

Publications:

1) Cheng R, Liu YJ, Cui JW, Yang M, Liu XL, Li P, et al. Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells. Oncotarget. 2017 May 02;8(18):30252-64.

2) Zhou Y, Hao Y, Li Y, Li R, Wu R, Wang S, et al. Amplification and up-regulation of MIR30D was associated with disease progression of cervical squamous cell carcinomas. BMC cancer. 2017 Mar 29;17(1):230.

3) Fang Z, Zhang S, Wang Y, Shen S, Wang F, Hao Y, et al. Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins. BMC cancer. 2016 Sep 01;16:706.

4) Fang Z, Wu L, Wang L, Yang Y, Meng Y, Yang H. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis. Oral surgery, oral medicine, oral pathology and oral radiology. 2014 Jan;117(1):89-95.

5) Fang Z, Xiong Y, Zhang C, Li J, Liu L, Li M, et al. Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population. Oncology letters. 2010 Sep;1(5):925-30.

6) Li S, Ma Y, Xie C, Wu Z, Kang Z, Fang Z, et al. EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression. Oncotarget. 2015 Sep 08;6(26):22587-97.

7) Tian Y, Zhang X, Hao Y, Fang Z, He Y. Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma. Melanoma research. 2014 Aug;24(4):335-41.

8) Xiong Y, Zhu JX, Fang ZY, Zeng CG, Zhang C, Qi GL, et al. Coseeded Schwann cells myelinate neurites from differentiated neural stem cells in neurotrophin-3-loaded PLGA carriers. International journal of nanomedicine. 2012;7:1977-89.

9) Zhang C, Xiong Y, Li J, Yang Y, Liu L, Wang W, et al. Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression. PloS one. 2012;7(2):e31207.

10) Fang Z, Xiong Y, Li J, Liu L, Zhang W, Zhang C, et al. APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2012 Jan;14(1):60-5.

11) Fang Z, Yao W, Xiong Y, Li J, Liu L, Shi L, et al. Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression. BMC cancer. 2011 May 24;11:195:1-11.

12) Fang Z, Xiong Y, Li J, Liu L, Li M, Zhang W, et al. Detection of APC gene deletions in colorectal malignancies using quantitative PCR in a Chinese population. Pathology oncology research : POR. 2011 Sep;17(3):657-61.

13) Xiong Y, Fang Z, Zhang C, Qi G, Liu W, Zhang W, et al. Copy number increase of HER-2 in colorectal cancers. Oncology letters. 2011 Mar;2(2):331-5.

14) Zhang C, Fang Z, Xiong Y, Li J, Liu L, Li M, et al. Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression. Acta biochimica et biophysica Sinica. 2010 Nov;42(11):834-8.

15) Fang Z, Xiong Y, Li J, Liu L, Li M, Zhang C, et al. Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression. Medical oncology. 2011 Dec;28(4):1017-22.

16) Fang Z, Yao W, Xiong Y, Zhang J, Liu L, Li J, et al. Functional elucidation and methylation-mediated downregulation of ITGA5 gene in breast cancer cell line MDA-MB-468. Journal of cellular biochemistry. 2010 Aug 01;110(5):1130-41.

17) Yu B, Shao Y, Zhang J, Dong XL, Liu WL, Yang H, et al. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. The British journal of dermatology. 2010 May;162(5):1038-43.

18) Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, et al. Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells. Current molecular medicine. 2013 Mar;13(3):417-28.

19) Yao W, Yu X, Fang Z, Yin P, Zhao C, Li N, et al. Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin beta1-actin complex in breast cancer cells. Journal of cellular and molecular medicine. 2012 Apr;16(4):824-35.

20) Fang Z, Yao W, Fu Y, Wang LY, Li Z, Yang Y, et al. Increased integrin alpha5beta1 heterodimer formation and reduced c-Jun expression are involved in integrin beta1 overexpression-mediated cell growth arrest. Journal of cellular biochemistry. 2010 Feb 01;109(2):383-95.

21) Yang Y, Zhou F, Fang Z, Wang L, Li Z, Sun L, et al. Post-transcriptional and post-translational regulation of PTEN by transforming growth factor-beta1. Journal of cellular biochemistry. 2009 Apr 15;106(6):1102-12.

22) Li Y, Sun L, Xu H, Fang Z, Yao W, Guo W, et al. Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin alphaVbeta3. Acta biochimica et biophysica Sinica. 2008 Jun;40(6):459-65.

23) Zhao H, Liang Y, Xu Z, Wang L, Zhou F, Li Z, et al. N-glycosylation affects the adhesive function of E-Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA-MB-435. Journal of cellular biochemistry. 2008 May 01;104(1):162-75.

24) Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, et al. Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. Journal of cellular biochemistry. 2007 Oct 15;102(3):704-18.

25) Fang Z, Fu Y, Liang Y, Li Z, Zhang W, Jin J, et al. Increased expression of integrin beta1 subunit enhances p21WAF1/Cip1 transcription through the Sp1 sites and p300-mediated histone acetylation in human hepatocellular carcinoma cells. Journal of cellular biochemistry. 2007 Jun 01;101(3):654-64.

26) Wang L, Liang Y, Li Z, Cai X, Zhang W, Wu G, et al. Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721. Journal of cellular biochemistry. 2007 Jan 01;100(1):230-41.

27) Fu Y, Wang LY, Liang YL, Jin JW, Fang ZY, Zha XL. Integrin beta(1A) upregulates p27 protein amount at the post-translational level in human hepatocellular carcinoma cell line SMMC-7721. Acta biochimica et biophysica Sinica. 2006 Aug;38(8):523-30.

 

 


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